کتاب Ocular Neuroprotection

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Ocular Neuroprotection

edited by

Leonard A. Levin

University of Wisconsin-Madison

Madison, Wisconsin, U.S. A.

Adriana Di Polo

University of Montreal

Montreal, Quebec, Canada

MARCEL D E K K E R

NEW YORK - BASEL

Neuroprotection comprises a broad range of therapeutic strategies aimed at preventing

death of neurons in trauma or disease. As applied to ocular disorders,

neuroprotection has received enormous attention in past years because of its potential

for treating diseases that were heretofore untreatable or difficult to treat,

including disorders primarily involving death of photoreceptors (such as in macular

degeneration, retinitis pigmentosa, and retinal detachment) or retinal ganglion

cells (such as in glaucoma).

The goal of this book is to provide the reader with up-to-date ocular neuroprotection

research methods that are used in leading laboratories worldwide.

Chapters 1 through 15 focus on research methods at the laboratory level, with

emphasis on various cell culture and animal models, classes of neuroprotective

drugs, biochemical and cellular outcome measures, and applicability to human

disease. Chapters 16 through 18 focus on how clinical trials of neuroprotection

may be carried out, concentrating on issues of recruitment, outcome measures,

and requirements of regulatory agencies.

The information conveyed in this book is intended to be practical. The

chapters address the nuts and bolts of the actual methods themselves, along with

potential problems, solutions to those problems, potential shortcuts (and contraindications

to shortcuts), and specific suppliers, where appropriate. The book is

not intended to be an exhaustive presentation of research data or theories, but

rather to provide a focused description of useful methods for conducting neuroprotection

research.

This book will acquaint those considering research in the area with the

major techniques, tools, and issues in ocular neuroprotection, while investigators

with experience in neuroprotection research may benefit from exposure to new

models, methodologies, and clinical approaches. Regardless of the reader’s experience,

this volume will be an invaluable resource

We sincerely thank all the contributors—leading scientists in their fields—

who have generously shared their knowledge and expertise in each chapter.

 

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BLACKWELL’S NEUROLOGY AND PSYCHIATRY ACCESS SERIES

Child and Adolescent

Neurology

SECOND EDITION

EDITED BY

Ronald B. David, MD, FAAP, FAAN

Richmond

Virginia

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